INTERFRACTION VARIATION AND DOSIMETRIC CHANGES IN PATIENTS WITH CERVICAL CANCER TREATED WITH INTRACAVITARY BRACHYTHERAPY

Interfraction Variation and Dosimetric Changes in Patients With Cervical Cancer Treated With Intracavitary Brachytherapy

Purpose: Intracavitary brachytherapy is integral in the treatment of cervical cancer.Because of interfraction variation, the current standard is replanning with every fraction.This study aimed to determine whether there was a difference in relative dosimetry if the source position and dwell time of the first fraction were applied to subsequent frac

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AMP-activated protein kinase fortifies epithelial tight junctions during energetic stress via its effector GIV/Girdin

Loss of epithelial polarity impacts organ development and function; it is also oncogenic.AMPK, a key sensor of metabolic stress stabilizes cell-cell junctions and maintains epithelial polarity; its activation by Metformin protects the epithelial barrier Racks / Carriers against stress and suppresses tumorigenesis.How AMPK protects the epithelium re

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